Yang Group is dedicated to addressing the clinical needs of precision therapy for major diseases by focusing on cutting-edge technologies such as functional nucleic acids, genetic engineering, and intelligent delivery systems. The group develops novel strategies for tumor therapy and immune microenvironment modulation. The group research spans interdisciplinary fields including nanomedicine, nucleic acid chemistry, genetic and cellular engineering, and immune microenvironment regulation, establishing an integrated research framework encompassing "nucleic acid/nanotechnology — biological effects — mechanistic elucidation — clinical translation". The group is committed to advancing diagnostic and therapeutic innovations for major diseases, including tumors, immune-related disorders (e.g., myocardial infarction, acute lung injury, pulmonary fibrosis, atherosclerosis, osteoporosis), and neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease).
Current Research Directions:
1. Development of Intelligent Nanodrug Delivery Systems
Designing novel delivery systems with targeted recognition, microenvironment responsiveness, and controlled release capabilities to overcome biological barriers, achieve precise drug delivery, and modulate the immune microenvironment.
2. DNA Molecular Engineering and Functional Nucleic Acid Design
Advancing nucleic acid chemical technologies, including functional nucleic acids and DNA nanotechnology, to establish efficient nucleic acid modification and assembly platforms for cell surface engineering, disease diagnosis, and targeted therapy, thereby accelerating the development of nucleic acid drugs.
3. Genetic Engineering and Cell Therapy Strategies
Enhancing cell function, enabling specific recognition, and amplifying therapeutic effects through genetic engineering and cell-surface DNA molecular engineering to develop next-generation cell therapies for treating various immune-related diseases.
4. Novel Precision Diagnosis and Treatment Strategies for Multiple Diseases
Developing integrated platforms combining diagnosis, imaging, and therapy to promote personalized treatment in oncology, immune-related diseases (e.g., acute lung injury, pulmonary fibrosis, atherosclerosis, myocardial infarction, osteoporosis), and neurodegenerative disorders (e.g., Alzheimer's disease, Parkinson's disease).
6. Mechanistic Analysis and Modulation of Tumor and Immune Microenvironments
Investigating the microenvironmental features of tumors and immune-related diseases to systematically analyze their physicochemical properties, metabolic reprogramming, and immune regulatory networks. By integrating multi-omics analysis and functional experiments, the group aims to elucidate the dynamic interactions within tumor-immune microenvironments, construct intervention networks targeting key regulatory nodes, and provide theoretical foundations and strategic guidance for precision targeted therapies.
