Yu Yang
Professor | Ph.D. Supervisor
Institute of Molecular Medicine, School of Medicine, Shanghai Jiao Tong University
Enrollment / Major Fields
Chemistry, Materials Science, Oncology, Immunology (and related disciplines)
Research Areas
Principal Investigator Bio
Prof. Yu Yang is a Professor and Ph.D. Supervisor at the Institute of Molecular Medicine, Shanghai Jiao Tong University School of Medicine. He is a recipient of the National Overseas High-level Youth Talent Program. He earned his degree in Biomedical Science from the University of Macau and completed postdoctoral training in molecular medicine at the University of Florida.
Driven by unmet clinical needs, Prof. Yang’s group develops functional nucleic-acid and genetic-engineering technologies to remodel the tumor and immune microenvironments, enabling next-generation therapeutic strategies. He has published 80+ SCI-indexed papers in leading journals, including Chem, Science Advances, J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., Nano Lett., ACS Nano, and ACS Cent. Sci. His work has received 10,000+ citations (H-index: 55), and multiple publications have been recognized as ESI Highly Cited Papers.
Prof. Yang’s honors include the Shanghai Shuguang Scholar Award (2024), the Macao Science and Technology Award—Postgraduate R&D Prize (2018), the Baxter China Young Investigator Award (First Prize, 2019), and the Veblea Fellow Award (2025) from the Veblea Association (USA). He also serves on professional committees of the Chinese Society for Biomaterials and the Chinese Society of Ultrasound in Medicine, and is a Youth Editorial Board Member for Nano-Micro Letters, Exploration, and Asian Journal of Pharmaceutical Sciences (AJPS).
Lab Website: http://www.yanglab.com.cn
Awards & Honors
· Member, Nucleic Acid Analysis Branch, China Analytical and Testing Association (2025–2030)
· Veblea Fellow Award, Veblea Association (USA) (2025)
· Shanghai Shuguang Scholar Award (2024)
· PI, National Key R&D Program of China (2023)
· Committee Member, Youth Working Committee, Chinese Society for Biomaterials (2023)
· Youth Editorial Board Member, Nano-Micro Letters (2023)
· Youth Editorial Board Member, Exploration (2023)
· Youth Editorial Board Member, Asian Journal of Pharmaceutical Sciences (2023)
· PI, Excellent Young Scientists Fund (Overseas), NSFC (2021)
· Baxter China Young Investigator Award, First Prize (2019)
Representative Publications：
1. Xueliang Liu, Yuqing Li, Xinfeng Dai, Zhicheng Huang, Jiabei Li, Chuhuang Dong, Ziliang Dong, Dali Wei, Huayuan Zhou, Zhuang Liu*, Yu Yang*, Weihong Tan*. Manganese-Coordinated Polyvalent Aptameric System (COMPASS) Enables DC-Targeted mRNA/Mn2+ Co-Delivery for Cancer Immunotherapy, Angewandte Chemie International Edition, 2026, e19216. (IF=16.6)
2. Jingqi Chen; Yuqing Li*; Xueliang Liu; Hongyi Li; Jiawei Zhu; Rui Ma; Linxin Tian; Lu Yu; Jiabei Li; Zhuang Liu; Weihong Tan; Yu Yang*. Antigen Spatial Matching Polyaptamer Nanostructure to Block Coronavirus Infection and Alleviate Inflammation. Chem, 2025, 11, 2, 102354. (IF=22.8)
3. Dongsheng Mao; Wenxing Li; Xueliang Liu; Jingqi Chen; Dali Wei; Lei Luo; Qianqin Yuan; Yu Yang*; Xiaoli Zhu*; Weihong Tan. Rolling circle amplification-based DNA-enzyme nanostructure for immobilization and functionalization of enzymes. Chem, 2025, 11, 2, 102335. (IF=22.8)
4. Xuan Wang#, Linxin Tian#, Yuqing Li*, Wei Yao, Jiawei Zhu, Huayuan Zhou, Ganghui Chen, Tongkai Chen*, Zhuang Liu, Weihong Tan*, Yu Yang*. A Universal Albumin Drugs-Cored Spherical Nucleic Acid (ad-SNA) Platform for Targeted Drug Delivery, Angewandte Chemie International Edition, 2025, 64, 19, e202421949. (IF=16.9)
5. Shuang Wang#, Xueliang Liu#, Dali Wei#, Huayuan Zhou, Jiawei Zhu, Qing Yu, Lei Luo, Xinfeng Dai, Yiting Jiang, Lu Yu, Yu Yang*, Weihong Tan*. Polyvalent Aptamer Nanodrug Conjugates Enable Efficient Tumor Cuproptosis Therapy through Copper Overload and Glutathione Depletion, Journal of the American Chemical Society, 2024, 146(44): 30033-30045. (IF=15.0)
6. Yuting Huang#, Xueliang Liu#, Jiawei Zhu#, Zhejie Chen, Lu Yu, Xin Huang, Chuhuang Dong, Jiabei Li, Huayuan Zhou, Yu Yang*, Weihong Tan. Enzyme core spherical nucleic acid that enables enhanced cuproptosis and anti-tumor immune response through alleviating tumor hypoxia, Journal of the American Chemical Society, 2024, 146(20): 13805-13816. (Cover Paper) (IF=15.0)
7. Dongsheng Mao#, Ziliang Dong, Xueliang Liu, Wenxing Li, Hongyi Li, Chao Gu, Ganghui Chen, Xiaoli Zhu*, Yu Yang*. An Intelligent DNA Nanoreactor for Easy-to-Read In Vivo Tumor Imaging and Precise Therapy, Angewandte Chemie International Edition, 2024, 63(7): e202311309. (IF=16.6)
8. Xueliang Liu#, Binghua Chen#, Jingqi Chen#, Xuan Wang, Xinfeng Dai, Yuqing Li, Huayuan Zhou, Lianming Wu*, Zhuang Liu*, Yu Yang*. A Cardiac-Targeted Nanozyme Interrupts the Inflammation-Free Radical Cycle in Myocardial Infarction, Advanced Materials, 2024, 36(2):2308477. (IF=29.4)
9. Xueliang Liu#, Fan Li#, Ziliang Dong, Chao Gu, Dongsheng Mao , Jingqi Chen, Lei Luo, Yuting Huang, Jie Xiao*, Zhanchun Li*, Zhuang Liu*, Yu Yang*. Metal-polyDNA nanoparticles reconstruct osteoporotic microenvironment for enhanced osteoporosis treatment, Science Advances, 2023, 9(31), eadf3329. Highlighted by Nat. Rev. Rheumatol. 2023,19, 606. (IF=13.6)
10. Yuqing Li#, Xueliang Liu#, Lu Yu, Xin Huang, Xuan Wang, Da Han*, Yu Yang*, and Zhuang Liu*. Covalent LYTAC Enabled by DNA Aptamers for Immune Checkpoint Degradation Therapy, Journal of the American Chemical Society, 2023,145, 45, 24506-24521. (IF=15.0)
11. Chao Gu#, Xueliang Liu#, Lei Luo, Jingqi Chen, Xiao Zhou, Ganghui Chen, Xin Huang, Lu Yu, Qian Chen, Yu Yang*, and Yang Yang*. Metal-DNA Nanocomplexes Enhance Chemo-dynamic Therapy by Inhibiting Autophagy-Mediated Resistance, Angewandte Chemie International Edition, 2023, 62(50): e202307020. (IF=16.6)
12. Xiaohao Liu#, Dongsheng Mao#, Yuchen Song, Liucun Zhu, Albertina N Isak, Cuicui Lu, Guoli Deng, Feng Chen, Fenyong Sun*, Yu Yang*, Xiaoli Zhu*, Weihong Tan*. Computer-aided design of reversible hybridization chain reaction (CAD-HCR) enables multiplexed single-cell spatial proteomics imaging. Science Advances, 2022, 8(2), eabk0133. (IF=13.6)
13. Yu Yang, Jun Xu, Yang Sun, Liuting Mo, Bo Liu, Xiaoshu Pan, Zhuang Liu*, Weihong Tan*. Aptamer-Based Logic Computing Reaction on Living Cells to Enable Non-Antibody Immune Checkpoint Blockade Therapy. Journal of the American Chemical Society, 2021, 143, 22, 8391-8401. (IF=15.0)
14. Yu Yang, Zhuang Liu*. Chemiluminescent Nanosystems for Imaging Cancer Chemodynamic Therapy. Chem, 2020, 6(9): 2127-2129. (IF=22.804)
15. Yu Yang, Wenjun Zhu, Ziliang Dong, Yu Chao, Lai Xu*, Meiwan Chen*, Zhuang Liu*. 1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy. Advanced Materials (Cover Paper), 2017, 29(40). (IF=29.4)