Yu Yang
Ph.D. Supervisor | Professor
Research Focus
Cell-surface DNA molecular engineering
Nucleic acid biomaterials
Immune engineering
Precision immunotherapy
Nanobiotechnology
Tutorial introduction
Yu Yang, Ph.D.
Yu Yang is a professor and doctoral supervisor at the Institute of Molecular Medicine at Shanghai Jiao Tong University School of Medicine. Prof. Yang is a recipient of both the National Overseas Excellent Young Scholars Programme and the Shanghai High-Level Overseas Talent Programme. He earned his PhD in Biomedical Sciences at the University of Macau, subsequently conducting postdoctoral research in molecular medicine under the mentorship of Academician Weihong Tan at the University of Florida in the USA.
Guided by clinical needs, his recent work focuses on developing tumor and immune microenvironment intervention technologies and related therapies based on functional nucleic acids and genetic engineering. Over the past five years, he has published over 40 SCI-indexed papers as a corresponding author in top-tier journals, including Chem (3), Science Advances (2), Journal of the American Chemical Society (4), Angewandte Chemie International Edition (3), Advanced Materials (2), Nano Letters (2), ACS Nano (2), and ACS Central Science (2). His publications have garnered over 9,000 citations with an H-index of 50, and multiple papers have been recognized as ESI Highly Cited Papers.
Prof. Yang has led several key research projects, including those funded by the National Key Research and Development Programme of China, the National Natural Science Foundation of China and the Young Scientists Fund Project of the National Natural Science Foundation of China. He has received several awards, including the Shanghai Shuguang Scholar Award (2024), the University of Macau Postgraduate Research Award in Science and Technology (2018) and the Baxter China Young Investigator Award (First Prize, 2019). He is a committee member of the Youth Working Committee of the Chinese Society for Biomaterials and a council member of the World Federation of Chinese Medicine Societies (Herbal Preparations Committee). He is also a Youth Editorial Board member for Nano Micro Letters, Exploration, and AJPS.
Lab Website: http://www.yanglab.com.cn
Grants, Awards & Honors
? Shanghai Shuguang Scholar Award (2024)
? The National Key Research and Development Program of China (PI, 2023)
? Member of the Youth Committee of the Chinese Society for Biomaterials (2023)
? Excellent Young Scientists Fund (Overseas), NSFC, (PI, 2021)
? First Prize in the Baxter China Young Scientist Award (2019)
? First Prize in the Macao Science and Technology Award for Graduate Student Research and Development (2018)
? Council Member of the World Federation of Chinese Medicine Societies' Committee on Traditional Chinese Medicine Pharmacy (2018-2022)
Representative Publications：
1. Xueliang Liu#, Fan Li#, Ziliang Dong, Chao Gu, Dongsheng Mao , Jingqi Chen, Lei Luo, Yuting Huang, Jie Xiao*, Zhanchun Li*, Zhuang Liu*, Yu Yang*. Metal-polyDNA nanoparticles reconstruct osteoporotic microenvironment for enhanced osteoporosis treatment, Science Advances, 2023, 9(31), eadf3329. Highlighted by Nat. Rev. Rheumatol. 2023,19, 606. (IF=13.6)
2. Xiaohao Liu#, Dongsheng Mao#, Yuchen Song, Liucun Zhu, Albertina N Isak, Cuicui Lu, Guoli Deng, Feng Chen, Fenyong Sun*, Yu Yang*, Xiaoli Zhu*, Weihong Tan*. Computer-aided design of reversible hybridization chain reaction (CAD-HCR) enables multiplexed single-cell spatial proteomics imaging, Science Advances, 2022, 8 (2), eabk0133. (IF=13.6)
3. Yuting Huang#, Xueliang Liu#, Jiawei Zhu#, Zhejie Chen, Lu Yu, Xin Huang, Chuhuang Dong, Jiabei Li, Huayuan Zhou, Yu Yang*, Weihong Tan. Enzyme core spherical nucleic acid that enables enhanced cuproptosis and anti-tumor immune response through alleviating tumor hypoxia, Journal of the American Chemical Society, 2024. (IF=15.0)
4. Yu Yang, Zhuang Liu*. Chemiluminescent Nanosystems for Imaging Cancer Chemodynamic Therapy. Chem, 2020, 6 (9), 2127-2129. (IF=22.804)
5. Yuqing Li#, Xueliang Liu#, Lu Yu, Xin Huang, Xuan Wang, Da Han*, Yu Yang*, and Zhuang Liu*. Covalent LYTAC Enabled by DNA Aptamers for Immune Checkpoint Degradation Therapy, Journal of the American Chemical Society, 2023,145, 45, 24506–24521. (IF=15.0)
6. Yu Yang, Jun Xu, Yang Sun, Liuting Mo, Bo Liu, Xiaoshu Pan, Zhuang Liu*, Weihong Tan*. Aptamer-Based Logic Computing Reaction on Living Cells to Enable Non-Antibody Immune Checkpoint Blockade Therapy.Journal of the American Chemical Society, 2021, 143, 22, 8391–8401. (IF=16.383)
7. Chao Gu#, Xueliang Liu#, Lei Luo, Jingqi Chen, Xiao Zhou, Ganghui Chen, Xin Huang, Lu Yu, Qian Chen, Yu Yang*, and Yang Yang*. Metal-DNA Nanocomplexes Enhance Chemo-dynamic Therapy by Inhibiting Autophagy-Mediated Resistance, Angewandte Chemie International Edition, 2023, 62(50): e202307020. (IF=16.6)
8. Dongsheng Mao#, Ziliang Dong, Xueliang Liu, Wenxing Li, Hongyi Li, Chao Gu, Ganghui Chen, Xiaoli Zhu, Yu Yang*. An Intelligent DNA Nanoreactor for Easy-to-Read In Vivo Tumor Imaging and Precise Therapy, Angewandte Chemie International Edition, 2024, 63(7): e202311309. (IF=16.6)
9. Xueliang Liu#, Binghua Chen# Jingqi Chen#, Xuan Wang, Xinfeng Dai, Yuqing Li, Huayuan Zhou, Lianming Wu*, Zhuang Liu*,Yu Yang*.A Cardiac-Targeted Nanozyme Interrupts the Inflammation-Free Radical Cycle in Myocardial Infarction. Advanced Materials, 2024, 36(2): 2308477. (IF=29.4)
10. Yu Yang, WenjunZhu, Ziliang Dong, Yu Chao, Lai Xu*, Meiwan Chen*, Zhuang Liu*. 1D Coordination Polymer Nanofibers for Low-Temperature Photothermal Therapy. Advanced Materials, 2017, 29(40). (IF=21.950)
11. Yang Sun#, Liuting Mo#, Xiaoxiao Hu#, Die Yu, Sitao Xie, Jianglin Li, Zilong Zhao, Xiaohong Fang, Mao Ye*, Liping Qiu*, Weihong Tan*,Yu Yang*. Bispecific Aptamer-Based Recognition-then-Conjugation Strategy for PD1/PDL1 Axis Blockade and Enhanced Immunotherapy. ACS Nano, 2023, 16(12): 21129-21138. (IF=17.1)
12. Renyikun Yuan, Yuqing Li, Shan Han, Xinxin Chen, Jingqi Chen, Jia He, Hongwei Gao*, Yang Yang*, Shilin Yang, Yu Yang*. Fe-Curcumin Nanozyme-Mediated Reactive Oxygen Species Scavenging and Anti-Inflammation for Acute Lung Injury. ACS Central Science, 2022,8(1):10-21. (IF=18.728)